Επ.Καθ.Claude Nos, M.D.PhD

Born 11 October 1962, Neuilly-sur-Seine (France) – French nationality

Language : English Fluent

Professional adresses :

Department of Gynecologic and Oncologic Surgery, Hôpital Européen George Pompidou,

12 Rue Leblanc, 75015 Paris, France

Tel: 0033156093583

E-mail:  [email protected]

The Paris Breast Center

7, Avenue Bugeaud, 75 016 Paris

Tel : 00331 45 630000 

HOSPITAL POSITIONS

1981-1987: Medical studies in the Faculty of Medicine – University of Nice
1988-1989: Interne des Hôpitaux de Paris, Residency in Gynecologic Surgery, Oncologic Surgery and
General Surgery
1989- 1990: Military Service in an Army Hospital (Begin)
1990-1993: Interne des Hôpitaux de Paris (continued)
1993- 1996 : Chef de clinique-Assistant des Hôpitaux de Paris. (equivalent to “Senior Register” (Speciality in Gynecologic surgery)
1996-2005: Assistant Professor at the Institut Curie –Paris
2005: Part-time Surgeon in the Department of Gynecologic and Oncologic Surgery, Hôpital Européen Georges Pompidou and Associate Surgeon at the Paris Breast Center.

ACADEMIC TITLES

Medical Doctor, 1993
Certification in Gynecologic Surgery, 1993
Certification in Oncologic Surgery, 1998
Certification in General Surgery, 2007

UNIVERSITY DIPLOMAS

Gynecologic and Obstetric Ultra Sound, 1995
Surgical Techniques in Reconstructive Breast Cancer Surgery, 1998
MicroSurgery, 2000

MISCELANEUS

Member of the French Society of Senology
Member of the French Association of Surgery
Member of the French Society of Gynecologic Oncology
Member of the International Sentinel Node Society

TEACHING ACTIVITIES

Specialised lectures to residents in oncology, breast surgery and radiotherapy since 1998 in several Specialised Schools and Institutes such as the Centre René Huguenin, the Institut Curie, the European School of Oncology (ESO) and European School of Surgey (EEC), including live surgery.

CLINICAL AND RESEARCH ACTIVITIES

I was first trained and graduated as a gynaecologist surgeon. In 1996, I was recruited at the Institut Curie and I progressively focussed my activities on breast cancer surgery, acquiring specialist skills in reconstructive breast surgery, which became an important part of my professional activity. After a few years, I concentrated on sentinel node biopsy and issued numerous related publications. At the moment, I am in the process of experimenting a new technique named Axillary Reverse Mapping for which I am the principal investigator through a National Multicentric Study “Sentibras” .
In close association with Dr K. B. Clough (Chief of the Department of Breast and General Surgery in Institut Curie from 1996 to 2004), I have also focused my research on the extension of the surgical techniques for breast cancer patients and have contributed to the development of an « oncoplastic » approach for tumors that would not be suitable for standard conservative surgery. These oncoplastic procedures extend the scope of breast surgery, traditionally limited to wide local excision or mastectomy.
In 2005 I left the Institut Curie to assist Dr K. Clough in the establishment of the Paris Breast Centre, France’s first Breast Center. The Paris Breast Center treats more than 500 new breast cancer cases per year and is one of the leading private institutions in France for treatment and education. In parallel, I remained in the Public Health Sector at the Hospital Europeen George Pompidou ( Service of the Prof F LECURU) with a view, inter alia, to pursue my research work, in particular the above mentioned “Sentibras” Protocol.

AUTHORS or COAUTHOR of INTERNATIONAL PUBLICATIONS

1. Postoperative lymphocysts after lymphadenectomy for gynaecological malignancies: preventive techniques and prospects.Achouri A, Huchon C, Bats AS, Bensaïd C, Nos C, Lécuru F. Eur J Obstet Gynecol Reprod Biol. 2012 Apr;161(2):125-9.
2. Updated follow-up of patients treated with the oncoplastic “Crescent” technique for breast cancer. Aljarrah A, Nos C, Nasr R, Clough KB, Bats AS, Lecuru F. Breast. 2011 Dec 18.
3. Non sentinel node involvement prediction for sentinel node micrometastases in breast cancer: nomogram validation and comparison with other models. Houvenaeghel G, Bannier M, Nos C, Giard S, Mignotte H, Jacquemier J, Martino M, Esterni B, Belichard C, Classe JM, Tunon de Lara C, Cohen M, Payan R, Blanchot J, Rouanet P, Penault-Llorca F, Bonnier P, Fournet S, Agostini A, Marchal F, Garbay JR. Breast. 2012 Apr;21(2):204-9. Epub 2011 Oct 19
4. Sentinel lymph node biopsy and axillary reverse mapping: a tailoring axillary staging in breast cancer]. Cusumano P, Bleret V, Nos C, Hustinx R, Lilet H, Gomez P, Lifrange E. Rev Med Liege. 2011 May-Jun; 66(5-6):336-40. French.
5. Diagnostic performance of one-step nucleic acid amplification for intraoperative sentinel node metastasis detection in breast cancer patients. Le Frère-Belda MA, Bats AS, Gillaizeau F, Poulet B, Clough KB, Nos C, Peoc’h M, Seffert P, Bouteille C, Leroux A, Guillemin F, Blanc-Fournier C, Crouet H, Arnould L, Cuisenier J, Penault-Llorca F, Gimbergues P, Jacquemier J, Houvenaeghel G, Chatellier G, Lécuru F. Int J Cancer. 2012 May 15;130(10):2377-86.
6. Adipose-tissue grafting to the post-mastectomy irradiated chest wall: preparing the ground for implant reconstruction.Sarfati I, Ihrai T, Kaufman G, Nos C, Clough KB. J Plast Reconstr Aesthet Surg. 2011 Sep;64(9):1161-6. Epub 2011 Apr 22
7. Clear margins for invasive lobular carcinoma: a surgical challenge. Sakr RA, Poulet B, Kaufman GJ, Nos C, Clough KB. Eur J Surg Oncol. 2011 Apr;37(4):350-6. Epub 2011 Feb 1.
8. Current indications of lymphadenectomy in endometrial cancer. Bats AS, Bensaïd C, Huchon C, Scarabin C, Nos C, Lécuru F. Gynecol Obstet Fertil. 2010 Dec;38(12):754-9.
9. The fat trap: a simple method for harvesting large amounts of adipose tissue during liposuction. Ihrai T, Clough KB, Nos C, Sarfati I. Plast Reconstr Surg. 2010 Oct;126(4):206e.
10. New anatomical classification of the axilla with implications for sentinel node biopsy. Clough KB, Nasr R, Nos C, Vieira M, Inguenault C, Poulet B. Br J Surg. 2010 Nov;97(11):1659-65
11. Silicone migration to the contralateral axillary lymph nodes and breast after highly cohesive silicone gel implant failure: a case report.Kaufman GJ, Sakr RA, Inguenault C, Sarfati I, Nos C, Clough KB. Cases J. 2009 Mar 10;2:6420
12. Response of V. Lavoué to the article of G Akerman et al. Simplified technique of radioguided occult lesion localization in breast cancer: techniques of the future? Gynecol Obstet Fertil 2009;37:45-9 Lavoué V, Nos C, Lécuru F. Gynecol Obstet Fertil. 2009 May;37(5):460-1.
13. Breast Actinomyces neuii abscess simulating primary malignancy: a case diagnosed by fine-needle aspiration.Lacoste C, Escande MC, Jammet P, Nos C .Diagn Cytopathol. 2009 Apr;37(4):311-2..
14. Improving breast cancer surgery: a classification and quadrant per quadrant atlas for oncoplastic surgery.Clough KB, Kaufman GJ, Nos C, Buccimazza I, Sarfati IM. Ann Surg Oncol. 2010 May;17(5):1375-91.
15. Surgical treatment of early endometrial cancer: what are the benefits of laparoscopy? Capmas P, Bats AS, Bensaid C, Huchon C, Scarabin C, Nos C, Lécuru F.J Gynecol Obstet Biol Reprod (Paris). 2009 Nov;38(7):537-44.
16. Lobular phenotype related to occult-metastatic spread in axillary sentinel node and/or bone marrow in breast carcinoma. Vincent-Salomon A, Caly M, De Rycke Y, Fréneaux P, Klijanienko J, Laé M, Viard F, Nos C, Bidard FC, Alran S, Salmon R, Kirova Y, Pierga JY, Sigal-Zafrani B, Sastre-Garau X. Eur J Cancer. 2009 Jul;45(11):1979-86.
17. A nomogram predictive of non-sentinel lymph node involvement in breast cancer patients with a sentinel lymph node micrometastasis.Houvenaeghel G, Nos C, Giard S, Mignotte H, Esterni B, Jacquemier J, Buttarelli M, Classe JM, Cohen M, Rouanet P, Penault Llorca F, Bonnier P, Marchal F, Garbay JR, Fraisse J, Martel P, Fondrinier E, Tunon de Lara C, Rodier JF. Eur J Surg Oncol. 2009 Jul;35(7):690-5.
18. Adnexal masses management: a prospective multicentric observational studyHuchon C, Bats AS, Bensaïd C, Junger M, Nos C, Chatellier G, Lécuru F. Gynecol Obstet Fertil. 2008 Nov;36(11):1084-90.
19. Preliminary outcome of breast cancer located at the lower quadrant treated with a thoracomammary flap. Renouvel F, Nos C, Clough KB, Lecuru F.Bull Cancer. 2008 Aug;95(7):773-8. French
20. Combined axillary reverse mapping (ARM) technique for breast cancer patients requiring axillary dissection. Nos C, Kaufmann G, Clough KB, Collignon MA, Zerbib E, Cusumano P , Lecuru F. Ann Surg Oncol. 2008 Sep;15(9):2550-5.
21. Sentinel lymph nodes in endometrial cancer: is hysteroscopic injection valid? Clément D, Bats AS, Ghazzar-Pierquet N, Le Frere Belda MA, Larousserie F, Nos C , Lecuru F. Eur J Gynaecol Oncol. 2008;29(3):239-41.
22. Simplified technique of radioguided occult lesion localization (ROLL) plus sentinel lymph node biopsy (SNOLL) in breast carcinoma. Lavoué V, Nos C, Clough KB, Baghaie F, Zerbib E, Poulet B,Lefrère Belda MA, Ducellier A , Lecuru F. Ann Surg Oncol. 2008 Sep;15(9):2556-61.
23. Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse. Bidard FC, Vincent-Salomon A, Gomme S, Nos C, de Rycke Y, Thierry JP, Sigal-Zafrani B, Mignot L , Sastre garau X, Pierga JY ; Institut Curie Breast Cancer Study Group .Clin Cancer Res. 2008 Jun 1;14(11):3306-11.
24. Partial reconstruction after conservative treatment for breast cancer: classification of sequelae and treatment options. Clough KB, Nos C , Fitoussi A, Couturaud B, Inguenault C, Sarfati I. Ann Chir Plast Esthet. 2008 Apr;53(2):88-101
25. Comparison of different approaches in surgical management of early endometrial cancer] Bats AS, Chatellier G, Clément D, Larousserie F, Lefrère-Belda MA, Lecuru F, Nos C. Bull Cancer. 2007 Nov 1;94(11):1003-7.
26. Comments to the letter to the editor by dr. Ponzone . Nos C, Lesieur B, Clough KB, Collignon MA, Lecuru F..Ann Surg Oncol. 2008 Jan;15(1):392-3. Epub 2007 Nov 8.
27. Blue dye injection in the arm in order to conserve the lymphatic drainage of the arm in breast cancer patients requiring an axillary dissection. Nos C, Lesieur B, Clough KB, Lecruu F. Ann Surg Oncol 2007: 14 (9) : 2490-6.
28. Pathological response to preoperative concurrent chemo-radiotherapy for breast cancer: results of a phase II study. Bollet MA, Sigal-Zafrani B, Gambotti L, Extra JM. Meunier M, Nos C. Institut curie Breast Cancer Study Group. Eur J Cancer. 2006; 42(14):2286-95.
29. Impact of surgical access on staging of early borderline and invasive tumors of the ovary. Desfeux P, Chatellier G, Bats AS, Larrousserie F, Bensaid C, Nos C et Coll; Bull Cancer. 2006 ;93(7):723-30.
30. Micrometastases in sentinel lymph node in a multicentric study: predictive factors of nonsentinel lymph node involvement–Groupe des Chirurgiens de la Federation des Centres de Lutte Contre le Cancer . Houvenaeghel G, Nos C , Mignotte H, Classe JM, Giard S, Rouannet P et al. JCO 2006 ; 24(12) :1814-22.
31. Long follow-up of breast cancer revealed by clustered microcalcifications without palpable. Mass. Wehbe G, Sepanda M, Nos C, Falcou MC, Meunier M, Zafrani B, Fourquet A, Durand JC, Azoury J, Massoud E, Clough KB. J Med Liban. 2004; 52(1):2-7.
32. Stereotactic radioguided surgery by siteSelect for subclinical mammographic lesions. Doridot V, Meunier M, El Khoury C, Nos C, Vincent-Salomon A, Sigal-Zafrani B, Clough KB; Institut Curie Breast Cancer Group. Ann Surg Oncol. 2005 ;12(2):181-8.
33. Lymphocèles axillaires après curage ou prélèvement du ganglion sentinelle en cas de cancer du sein. Bijek JH, Aucouturier JS, Doridot V, Ghemari T, Nos C. Bull Cancer. 2005;92(2):179-83.
34. Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes–a study of 130 invasive ductal breast carcinomas. Reyal F, Stransky N, Bernard-Pierrot I, Vincent-Salomon A, de Rycke Y, Elvin P, Cassidy A, Graham A, Spraggon C, Desille Y, Fourquet A, Nos C, Pouillart P, Magdelenat H, Stoppa-Lyonnet D, Couturier J, Sigal-Zafrani B, Asselain B, Sastre- Garau X, Delattre O, Thiery JP, Radvanyi F Cancer Res. 2005;65 (4):1376-83.
35. Real-time quantitative PCR determination of urokinase-type plasminogene activator receptor (uPAR) expression of isolated micrometastatic cells from bone marrow of breast cancer patients. Pierga JY, Bonneton C, Magdelenat H, Vincent-salomon A, Nos C, Boudou E, Pouillart P, Thiery JP, de Cremoux P. Int J Cancer 2004 ;114(2) : 191-8.
36. Characteristics and outcome of 1755 operable breast cancers in women of 70 years of age . Pierga JY, Girre V, Laurence V, Asselain B, dieras V, Jouve M, Beuzeboc P, Fourquet A, Nos C, Sigal-Zafrani B, Pouillart P; Institut Curie Breast Cancer study Group. Breast 2004; 13 : 369-75.
37. MRI for surgical planning in patients with breast cancer who undergo preoperative chemotherapy. Thibault F, Nos C, Meunier M, El Khoury C, Ollivier L, Sigal-Zafrani B, Clough KB; Institut Curie Breast Cancer study Group. Am J Roentgenol 2004; 183: 1159-68.
38. Le ganglion sentinelle en routine dans les cancers du sein. Expérience de l’Institut Curie. Delahaye S, Benamor M, Nos C, Vincent-salomon A, El Khoury C, Doridot V, Sigal-Zafrani B, Clough KB ; Groupe sein de l’Institut Curie. Bull Cancer 2004 ; 91 : 641-7.
39. Enrichment methods to detect bone marrow micrometastases in breast carcinoma patients : clinical relevance. Choesmal V, Pierga JY, Nos C, Vincent-Salomon A, Sigal- Zafrani B, Thiery JP, Blin N. Breast Cancer Res 2004 ; : 556-70.
40. Les traitements conservateurs des cancers du sein . Marcollet A, Doridot V, Nos C. Rev Prat. 2004 ;54(8):847-53.
41. Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy. Vincent –Salomon A, Rousseau A, Jouve M, Beuzeboc P, Sigal-Zafrani B, Freneaux P, Rosty C, Nos C, Campana F, Klijanienko J, Al Ghuzlan A, Sastre-Garau X; Breast Cancer Study Group. Eur J Cancer. 2004 Jul;40(10):1502-8.
42. Les traitements conservateurs pour cancer du sein. Doridot V, Nos C, Aucouturier JS, Sigal-Zafrani B, Fourquet A, Clough KB. Cancer Radiother 2004 ; 8 : 21-8.
43. Pronostic value of cytokeratin 19 fragment (CYFRA 21-1) and cytokeratin positive cells in bone marrow samples of breast cancers patients. Pierga JY, Deneux L, Bonneton C, Vincent-salomon A, Nos C, Anract P, Magdelenat H, Pouillart P, Thiery JP. Int J Biol Markers 2004; 19: 23-31.
44. Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancers patients. Pierga JY, Bonneton C, Vincent-salomon A, de Cremoux P, Nos C, Blin N, Pouillart P, Thiery JP, Magdelenat H. Clin Cancer Res 2004; 10: 1392-400.
45. Prediction of tumour involvement in remaining axillary lymph nodes when the sentinel node in a woman with breast cancer contains metastases. Nos C, Harding –MacKean C, Trie A, Falcou MC, Sastre garau X, Clough KB. Br J Surg 2003 ; 11: 1354-60.
46. Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer. Pierga JY, Bonneton C, Magdelenat H, Vincent-salomon A, Nos C, Pouillart P, Thiery JP. Br J Cancer 2003; 89: 539-45.
47. Macroscopic quality control improves the reliability of blue dye only sentinel lymph node biopsy in breast cancer. Ann Surg Oncol 2003; 10: 525-30.
48. Impact of internal mammary sentinel node imaging in breast cancer. Benamor m, Nos C, Freneaux P, Clough KB. Clin Nucl Med 2003; 28: 375-8.
49. Oncoplastic techniques allow extensive resections for breast-conserving treatment of breast carcinomas. Clough KB, Lewis JS, Couturaud B, Fitoussi A, Nos C, Falcou MC. Ann Surg 2003 ; 237 : 26-34.
50. Histological detection of minimal metastatic involvment in axillary sentinel nodes : a rational basis for a sensitive methodology usable in daily practice. Freneaux P , Nos C, Vincent-Salomon A, Genin P, Sigal-Zafrani B, Al Ghuzlan A, Biriloni MJ, Clough KB, Sastre-Garau X. Mod. pathol. 2002 ; 15 : 641-6.
51. Sentinel node and breast cancer: fashion or surgical revolution ?. Clough KB, Nos C. Gynecol Obstet fertil 2002 ; 30 : 273-5.
52. Donor site sequelae after autologous breast reconstruction with an extend latissimus dorsi flap. Clough KB, Louis Sylvestre C, Fitoussi A, Couturaud B, Nos C. Plast Reconstr Surg. 2002 ; 109 : 1904-11.
53. Relevance of combined radiation and surgical treatment of early invasive carcinoma of the cervix. Charvolin JY, Nos C, de la Rochefordière A, de Margerie VJ, Durand JC, Clough KB. Bull Cancer 2001 ; 88 : 1207-12.
54. Sentinel node biopsy in breast cancer. Improving reliability of results. Nos C, Freneaux P, Louis sylvestre C, Sastre-Garau X, Clough KB. Presse med 2001 ; 30 ; 1394-8.
55. Sentinel lymph node detection for breast cancer : which patients are best suited for the patent blue dye only method of identification ? Nos C, Freneaux P, Guilbert S, Falcou MC, Salmon RJ, Clough KB. Ann Surg Oncol 2001 ; 8 : 438-43.
56. Prospective evaluation of late cosmetic results following breast reconstruction :I. Implant reconstruction. Clough KB , O’Donoghue JM, Fitoussi A, Nos C, Falcou MC. Plast ReconsT Surg 2001 ; 107 : 1702-9
57. Value of macroscopic analysis for authentification of axillary sentinel nodes detected by Patent Blue dye alone during breast cancer surgery. Fréneaux P, Nos C ,Charvolin JY, Vincent-Salomon A, Zafrani B, Salmon RJ, Clough KB, Sastre-Garau X. Ann Pathol 2000; 20 : 545-8.
58. Autologous breast reconstruction with latissimus dorsi flap. Rouzier R, Louis Sylvestre C, Nos C, Fitoussi A, Clough KB. Ann Chir Plast Esthet 2000 ; 45 : 583-8.
59. Diagnostic accuracy of sonography and combined sonographic assessment and sonographically guided cytology in non palpable solid breast lesions. Thibault F, Meunier M, Klijanienko J, El Khoury C, Nos c, Vincent-Salomon A, asselain B, Neuenschwander S. J Clin Ultrasound 2000; 28: 387-98.
60. Detection of MUC1-expressing mammary carcinoma cells in the peripherical blood of breast cancer patients by real-time polymerase chain reaction. de Cremoux P, Extra JM, Denis MG, pierga JY, Bourstyn E, Nos C, Clough KB, Boudou E, Martin EC, Muller A, Pouillart P, Magdelenat H. Clin Cancer Res 2000; 6: 3117-22.
61. Sentinel node and operable breast cancer : utilization of blue dye injection : pilot study. Salmon RJ, Nos C, Lojodice F, Languille O, Remvikos Y, Vilcoq JR, Clough KB. Ann Chir 2000; 125: 253-8.
62. Sentinel lymph node detection in breast cancer . Experience of the Institut Curie Nos C, Freneaux P, Clough KB. J. Gynecol. Obstet. Biol. Reprod 2000 ; 29 : 251-3.
63. The sentinel lymph node in resectable cancer of the breast. Salmon RJ, Nos C, Clough KB. Chirurgie 1999; 124: 435-40
64. Sentinel lymph node detection in breast cancer . Experience from the Institut Curie Nos C, Bourgeois D, Freneaux P, Zafrani B, Salmon RJ, Clough KB. Bull cancer 1999; 86: 580-4.
65. Traitement conservateur des cancers du sein multifocaux. Etude à propos de 56 cas traités à L’Institut Curie de 1983 à 1989. Nos C, Bourgeois D, Darles S, Asselain B, Campana F, Zafrani B, Durand JC, Clough KB. Bull. Cancer 1999 ; 86 : 580-4.
66. Second-look for Ovarian Cancer : Laparoscopy or Laparotomy ? a prospective comparative study. Clough KB, Ladonne JM, Nos C, Renolleau C, Validire P, Durand JC. Gynecol Oncol. 1999, 72 : 411-7.
67. La chirurgie du creux axillaire en 1998. Nos C, Fitoussi A, Bourgeois D, Clough KB Cancer/ Radiother. 1998 ; 2 :475-81.
68. Cosmetic sequelae after conservative treatment of breast cancers. Clough KB, Cuminet J, Fitoussi A, Nos C, Mosseri V. Ann. Plas. Surg. 1998 ; 41 : 471-81.
69. Conservative treatment of lower pole breast cancers by bilateral mammaplasty and radiotherapy. Nos C, Fitoussi A, Bourgeois D, Fourquet A, Salmon RJ, Clough KB. Eur. J. Surg. Oncol. 1998 ; 24 : 508-14.
70. Conservative treatment of breast cancers by mammaplasty and irradiation: A new approach to lower quadrant tumors. Clough KB, Nos C, Salmon RJ , Soussaline M, Durand JC. Plast Reconstr Surg. 1995 ; 96: 363-70.
71. Stérilization reversal – A 226 cases study. Dubuisson JB, Chapron C, Nos C, Morice P, Aubriot FX, Garnier P. Hum. Reprod. 1995 ; 10 : 1145-51.
72. Dissection aortique aigüe pendant la grossesse. Heid M, Nos C, Cristalli B, Batellier J, Levardon M J. Gynecol. Obstet. Biol. Reprod. 1993 ; 22, 66-7
73. Hernie inguinale et endométriose. Cristalli B, Raguin E, Nos C, Levardon M. J. Gynecol. Obstet. Biol. Reprod. 1993 ; 22 : 149-50
74. Coelioscopie, appendicite et grossesse. Cristalli B, Nos C, Heid M, Levardon M J. Gynecol. Obstet. Biol. Reprod. 1992 ; 22 : 449-51.